Insights into Diabetic Kidney Disease Using Urinary Proteomics and Bioinformatics

Insights into Living with Kidney Disease

New Insights into Diabetic Kidney Disease: The Potential Pathogenesis and Therapeutic Targets

Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China Rush University, Chicago, IL, USA Chonbuk National University Medical School, Jeonju, Republic of Korea The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Yale University School of Medicine, New Haven, CT,...

Serum and Urinary Progranulin in Diabetic Kidney Disease

Progranulin has been recognized as an adipokine related to obesity, insulin resistance and type 2 diabetes mellitus (T2DM). There are scarce data regarding progranulin and kidney disease, but there are some data linking diabetic kidney disease (DKD) and increased progranulin levels. We aimed to better describe the relationship between serum and urinary progranulin levels and DKD in T2DM. This i...

Proteomics in Alzheimer's disease: insights into potential mechanisms of neurodegeneration.

Proteomics involves the identification of unknown proteins following their separation, often using two-dimensional electrophoresis, digestion of particular proteins of interest by trypsin, determination of the molecular weight of the resulting peptides, and database searching to make the identification of the proteins. Application of proteomics to Alzheimer's disease (AD), the major dementing d...

Identification of urinary proteins potentially associated with diabetic kidney disease

Diabetic nephropathy (DN) is the most common cause of chronic kidney disease. Although several parameters are used to evaluate renal damage, in many instances, there is no pathological change until damage is already advanced. Mass spectrometry-based proteomics is a novel tool to identify newer diagnostic markers. To identify urinary proteins associated with renal complications in diabetes, we c...